Nephrology

Plasmapheresis

A blood-cleansing treatment that removes harmful substances from the plasma.

Plasmapheresis

What is Plasmapheresis? 

Plasmapheresis, or plasma exchange therapy, is a procedure that filters the blood to remove abnormal antibodies, toxins, or proteins contributing to disease. During treatment, the patient’s blood is drawn, plasma is separated and replaced with a clean solution (such as saline or donor plasma), and the blood is returned to the body. 

This treatment helps to: 

  • Remove harmful antibodies or immune complexes 
  • Treat autoimmune and kidney-related diseases 
  • Manage severe cases of glomerulonephritis 
  • Support patients with neurological or hematological disorders 
  • Improve kidney and immune function in certain conditions 

What to expect during the procedure? 

  • Performed in a hospital or dialysis center 
  • Blood is withdrawn through a catheter or veins in the arms 
  • A machine separates plasma and replaces it with a substitute solution 
  • Each session lasts 2–4 hours, depending on the patient’s condition 
  • Mild fatigue or dizziness may occur afterward 
  • Multiple sessions may be needed for best results 

Why is it performed?

  • For autoimmune diseases affecting the kidneys (e.g., lupus nephritis)
  • To treat severe glomerulonephritis or vasculitis
  • To remove toxins or abnormal proteins from the blood
  • For patients with certain neurological or blood disorders
  • As an emergency treatment for rapidly progressive kidney failure

Risks and Considerations

  • Temporary low blood pressure or dizziness
  • Risk of infection at catheter site
  • Possible allergic reaction to replacement fluids
  • Bleeding or bruising from anticoagulants used
  • Electrolyte imbalances or mild fatigue after treatment

Early detection is important for managing the condition and preventing further complications.

Schedule a consultation today.

FAQs

Is plasmapheresis painful?
No, the procedure itself is not painful, though mild discomfort at the catheter site may occur.
Typically 2–4 hours, depending on the patient’s weight and blood volume.
The number varies—some patients need a few, others several sessions over days or weeks.
Yes, light food and fluids are usually allowed unless otherwise advised.
If you experience fever, shortness of breath, bleeding, or swelling at the catheter site, contact your doctor immediately.

Nephrology

Doral Health & Wellnes Kidney Department

Doral Health & Wellness Nephrology provides comprehensive care for patients with kidney disease. Our nephrologists offer a range of services, including diagnosis, treatment, and management of various kidney conditions. We provide personalized care, using advanced diagnostics and treatment plans, including dialysis and transplantation, to help you manage your kidney health and improve your quality of life.

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