What is a Nail Biopsy?
A nail biopsy removes a small sample of nail tissue to diagnose causes of pigment changes, thickening, tumors, or persistent nail problems. Techniques include:
- Punch biopsy of the nail bed or plate.
- Longitudinal excision involving the matrix for pigmented streaks.
- Shave/curettage of superficial lesions.
Performed with digital block anesthesia; the specimen is sent to pathology.
What to expect after a Nail Biopsy?
- Numbness for several hours from the local anesthetic
- Protective dressing or splint; keep clean and dry for 24–48 hours
- Throbbing pain the first night; elevation and NSAIDs help
- Light activity the next day; avoid tight shoes and trauma
- Stitches (if used) removed in 10–14 days; nail regrowth may take months
- Call if increasing redness, drainage, or fever occurs







